Painless Loss of Vision

Warning

Objectives

Facilitate accurate diagnosis in a patient with painless loss of vision and prevent permanent visual loss

  1. Provide a simple guide to recognition and initial assessment of painless loss of vision.
  2. Identify red flag signs/symptoms to aid triage for transfer to onward specialty care.
  3. Provide advice on immediate to short term management of patients with suspected retinal detachment, central retinal artery occlusion or central retinal vein occlusion. 

Scope

This guideline provides an overview of the pathophysiology of the main causes of painless loss of vision and guidance on assessing a patient with painless loss of vision

Risk factors and initial management are discussed for retinal detachment (RD), central retinal artery occlusion (CRAO), and central retinal vein occlusion (CRVO) including specific management of traumatic retinal detachment.

This guideline does not cover neurological causes of visual loss such as central lesions.

Audience

This guideline is intended for the use of registered healthcare professionals fulfilling a role in a forward medical location or in an emergency department on deployed operations

Initial Assessment & Management

The potential consequence of permanent blindness in a patient with new visual loss is a clear indication to prioritise onward referral to specialist care, however effective initial assessment can be valuable in facilitating triage, aiding effective liaison with reach-back clinicians, and informing first aid management.

RD, CRAO, and CRVO are all important differential diagnoses in acute visual loss and a typical history associated with these causes is outlined in the below table:

  Retinal Detachment (RD) Central Retinal Artery Occlusion (CRAO) Central Retinal Vein Occlusion (CRVO)
Onset Usually progressive Sudden, instantaneous Sudden, subacute (hours to days)
Pain None (unless traumatic) None - but note that giant cell arteritis can lead to CRAO and is itself a cause of pain None
Visual Loss Usually starts peripherally and moves centrally Severe/profound. Often complete visual loss in affected eye

Variable, mild to severe

Other Features Flashes and floaters Amaurosis fugax or temporary monocular vision loss could be present in a similar way with or without observed resolution of vision. RAPD Relative Afferent Pupillary Defect

Fundoscopy

(if available)

Vitreous opacities, tears, or detached retinal folds Free pigment or blood in vitreous, elevated/bullous or ‘corrugated’ retina

Pale retina, with “cherry red spot” on macula. Vessels may appear shrunken/non-perfused when compared to the normal eye with a cattle trucking or string of sausages appearance

Arterial emboli may be visible

(N.B. fundoscopic changes can take hours to form and fundoscopy may be normal. 

Multiple obvious retinal haemorrhages in all quadrants. Macular oedema.

Vitreous haemorrhage

It is important to note that normal fundoscopic changes cannot rule out RD or CRAO

 

CRAO

CRAO is analogous to a stroke and should be treated in the same way. The exception to this is that for those presenting within 6 hours ocular digital massage and urgent systemic IOP lowering may be helpful in encouraging an embolus to move further down the arteriole and reperfuse the retina - give acetazolamide 500mg orally (or IV) if available. 

Urgent transfer to an appropriate specialist unit should be your priority – retinal ganglion cell death can occur in 12-15 minutes and visual loss is often permanent. In patients with suspected amaurosis fugax where vision has returned, onward referral is still urgent as this is often a precursor to sustained visual loss with the same pathophysiology.

 

Retinal Detachment (RD)There are limited ‘first aid’ management options for RD and the primary management objective for a patient with suspected RD should be transfer on to an ophthalmologist – the rate of successful reattachment and visual outcomes is significantly greater if intervention is achieved prior to macula involvement. This should be the priority for any patient with suspected RD, especially those with visual acuity or visual field changes, or fundoscopic changes.

 

CRVOAs with any patient with visual loss, patients with suspected CRVO should also be transferred on to specialty ophthalmological care where possible. Careful review of cardiovascular risk factors is also indicated.

 

Trauma

Patients with a history of trauma should be managed using the ‘SHIELD AND SHIP’ protocol:

Place an eye shield or other rigid covering over the injured globe. Do not pad. Provide adequate analgesia and antiemesis. Initiate systemic antibiotic cover with fluoroquinolone as per deployed antimicrobial guidance, to ensure good ocular penetration and cover against gram negative organisms.

Where direct access to an eye surgeon is not available:

  • If possible, initiate telemedicine consultation with eye surgeon as soon as possible
  • Evacuate all vision-threatening injuries to see an eye surgeon within 12- 24 hours if possible.

Advanced Assessment & Management

Point of care ultrasonography

Where both equipment and expertise are available ultrasound can be used as an adjunct in the assessment of patients with suspected RD.

It is important to note that ultrasound should not be used in patients with a history of trauma, this is due to the risks posed by placing pressure on an eye with a traumatic injury. 

On ultrasound detached sections of retina appear as a hyperechoic line anterior to the choroid.

It is important to note that normal sonographic appearance does not exclude RD.

Retinal Detachment

Retinal detachment (RD) is the separation of the neurosensory retina from the underlying retinal pigment epithelium. This can be due to a break/tear in the retina (rhegmatogenous), traction from surrounding structures (tractional), or accumulation of subretinal fluid (exudative).

RD can be precipitated by trauma, inflammatory conditions (such as uveitis), posterior vitreous detachment, or associated with causative comorbidities.

While prompt treatment typically leads to good prognosis, RD left untreated can result in blindness

 

Risk Factors 

Risk factors for RD can be effectively broken down by the subcategory of RD which they precipitate:

Rhegmatogenous – Trauma - typically blunt (open or closed globe), myopia, previous cataract surgery, previous RD, family history of RD

Note that symptoms of traumatic RD may not develop for up to days after a traumatic event

Tractional – Increasing age, diabetes/diabetic retinopathy.

Exudative – Inflammatory eye conditions such as uveitis or scleritis, congenital eye conditions such as glaucoma or cataracts, local malignancy.

Likely next steps by specialist care

In the absence of clearer information from specialty care, patients with suspected RD could be advised to expect:

  • Further examination of visual acuity, fundoscopy, pressure testing, and slit lamp examination with drug adjuncts
  • Surgical intervention if RD confirmed which could include laser therapy/cryotherapy, vitrectomy, insertion of silicone ‘buckle’ on the sclera, or injection into the vitreous cavity

Central Retinal Artery Occlusion (CRAO)

CRAO describes interruption of blood flow through the retinal artery due to vasospasm or thrombus. It is often caused by dislodged emboli but can also be due to in situ thrombosis or as a complication of giant cell arteritis. In most of the population the central retinal artery is the only vascular supply to the inner retina and occlusion can therefore result in ischaemia and ultimately blindness in the affected eye. It is an ophthalmic emergency.

 

Risk Factors

Risk factors for CRAO can be considered to be the same as those for strokes and heart attacks. They include increased age, smoking history, hypercholesterolaemia, hypertension, history of previous stroke/MI, obesity, diabetes, and hypercoagulable state. 

 

Giant Cell Arteritis (GCA)

GCA (also known as temporal arteritis) is a vasculitis of the temporal artery and typically presents with jaw claudication, diplopia, headache, or scalp pain/tenderness. Risk factors include age over 50 years and female sex. A rare but serious consequence is visual loss due to optic nerve ischaemia or CRAO. Definitive diagnosis is through temporal artery biopsy or vascular ultrasonography, however raised ESR or CRP on blood testing can be a strong diagnostic indicator where GCA is suspected. Management is through high dose glucocorticoid steroids - see detailed guidance in headache CGO. 

Central Retinal Vein Occlusion (CRVO)

Central retinal vein occlusion describes an interruption to the venous drainage of the retina, most commonly due to thrombus however this can also be caused by other factors such as vasculitis. This occlusion leads to increased venous pressure which causes venous tortuosity, retinal haemorrhage, and surrounding oedema – all of which can be typically be identified on fundoscopy.

Common risk factors include diabetes, glaucoma, atherosclerosis, HTN, and smoking history.

CRVO can lead to neovascularisation and macular oedema which can ultimately result in retinal detachment or glaucoma. The mainstay of treatment is in risk factor management, however intravitreal Vascular Endothelial Growth Factor (VEGF) or corticosteroid injections can be indicated if neovascularisation or macular oedema is present.

Last reviewed: 13/07/2026

Next review date: 13/07/2027

References

References:

  1. BMJ Best Practice, 2025. Retinal detachment. [online] Available at: https://bestpractice.bmj.com/topics/en-gb/651 [Accessed 6 March 2025]

 

  1. National Institute for Health and Care Excellence (NICE), 2025. Retinal detachment: definition. [online] Available at: https://cks.nice.org.uk/topics/retinal-detachment/background-information/definition/ [Accessed 6 March 2025].

 

  1. Chauhan, K. et al., 2025. Traumatic retinal detachment: A contemporary update. Survey of Ophthalmology, 70(1), pp.75-85. Copyright © 2024 Elsevier Inc. Available at: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0039625724001012

 

  1. Clinical Guidelines, 2025. Ophthalmological emergencies. [online] Available at: https://cgo.mod.uk/clinical-guidelines-for-operations/treatment-guidelines/ophthalmology/ophthalmological-emergencies/ [Accessed 6 March 2025].

 

  1. Holliday, L. and Wilde, C., 2019. Retinal detachment. InnovAiT: Education and Inspiration for General Practice, [online] Available at: https://doi.org/10.1177/1755738019875162 [Accessed 6 March 2025].

 

  1. ​Gottlieb, M., et al. 2019. Point-of-Care Ocular Ultrasound for the Diagnosis of Retinal Detachment: A Systematic Review and Meta-Analysis. Academic Emergency Medicine, 26(8), pp.931-939. Available at: https://pubmed.ncbi.nlm.nih.gov/30636351/ [Accessed 20 March 2025].

 

  1. Lahham, S. et al., 2019. Role of Point of Care Ultrasound in the Diagnosis of Retinal Detachment in the Emergency Department. Open Access Emergency Medicine, 11, pp.265-270. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6859292/ [Accessed 20 March 2025].